CN
262020-05

Clinical evaluation of the effectiveness of fusion-induced asymmetric transcription assay-based reverse transcription droplet digital PCR for ALK detection in formalin-fixed paraffin-embedded samples from lung cancer

Carcinogenic anaplastic lymphoma kinase (ALK) gene rearrangement occurs in approximately 5%–7% of non-small cell lung cancer (NSCLC) patients. A fusion-induced asymmetric tran-scription assay (FIATA)-based reverse transcription was performed.

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282022-02

"Sample-to-Answer" Detection of Rare ctDNA Mutation from 2 mL Plasma with a Fully Integrated DNA Extraction and Digital Droplet PCR Microdevice for Liquid Biopsy

Crculating tumor DNA (ctDNA) refers to short fragments of acellular DNA that are derived from a tumor and freely circulate in the bloodstream. Yang et al. developed an integrated pathogen detection system combining DNA exaction and digital RPA.

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222020-02

ALK detection in lung cancer: identification of atypical and cryptic ALK rearrangements using an optimal algorithm

In most cases, dysregulated ALK expres-sion was caused by echinoderm microtubule-associated. This study focuses on ALK false negatives rather than false positives because of the data from our research.

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282022-02

Single-Tube Multiplex Digital Polymerase Chain Reaction Assay for Molecular Diagnosis and Prediction of Severity of Spinal Muscular Atrophy

Figure S-1 Test results of samples with different copy numbers of target genes diluted to a low concentration level.

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122021-08

Segmental duplication as potential biomarkers for non-invasive prenatal testing of aneuploidies

Determining fetal chromosomal aneuploidy is crucial for both pregnancy management and genetic counseling. Digital PCR was introduced for the detection to obtain absolute quantitative results. We showed that ddPCR rendered a successful NIPT .

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